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Int. J. Mol. Sci. 2017, 18(3), 680; doi:10.3390/ijms18030680

Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study

1
Department of Urology, Polyclinic Hospital, University of Catania, 95124 Catania, Italy
2
Department of Biomedical Sciences, University of Messina, 98125 Messina, Italy
3
Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico “G. Martino”, Torre Biologica, 5th Floor, Via C. Valeria, Gazzi, 98125 Messina, Italy
4
Department of Human Pathology, University of Messina, 98125 Messina, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jack A. Schalken
Received: 30 January 2017 / Revised: 16 March 2017 / Accepted: 17 March 2017 / Published: 22 March 2017
(This article belongs to the Special Issue Molecular Research on Urology)
View Full-Text   |   Download PDF [3958 KB, uploaded 22 March 2017]   |  

Abstract

Benign prostatic hyperplasia (BPH) treatment includes the apoptosis machinery modulation through the direct inhibition of caspase cascade. We previously demonstrated that Serenoa repens (Ser) with lycopene (Ly) and selenium (Se) reawakened apoptosis by reducing survivin and neuronal apoptosis inhibitory protein (NAIP) levels in rats. The aim of this study was to evaluate the effectiveness of Ser-Se-Ly association on survivin and NAIP expression in BPH patients. Ninety patients with lower urinary tract symptoms (LUTS) due to clinical BPH were included in this randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to receive placebo (Group BPH + placebo, n = 45) or Ser-Se-Ly association (Group BPH + Ser-Se-Ly; n = 45) for 3 months. At time 0, all patients underwent prostatic biopsies. After 3 months of treatment, they underwent prostatic re-biopsy and specimens were collected for molecular, morphological, and immunohistochemical analysis. After 3 months, survivin and NAIP were significantly decreased, while caspase-3 was significantly increased in BPH patients treated with Ser-Se-Ly when compared with the other group. In BPH patients treated with Ser-Se-Ly for 3 months, the glandular epithelium was formed by a single layer of cuboidal cells. PSA showed high immunoexpression in all BPH patients and a focal positivity in Ser-Se-Ly treated patients after 3 months. Evident prostate specific membrane antigen (PSMA) immunoexpression was shown in all BPH patients, while no positivity was present after Ser-Se-Ly administration. Ser-Se-Ly proved to be effective in promoting apoptosis in BPH patients. View Full-Text
Keywords: BPH; inhibitors of apoptosis proteins; Ser-Se-Ly association BPH; inhibitors of apoptosis proteins; Ser-Se-Ly association
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Morgia, G.; Micali, A.; Rinaldi, M.; Irrera, N.; Marini, H.; Puzzolo, D.; Pisani, A.; Privitera, S.; Russo, G.I.; Cimino, S.; Ieni, A.; Trichilo, V.; Altavilla, D.; Squadrito, F.; Minutoli, L. Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study. Int. J. Mol. Sci. 2017, 18, 680.

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