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Int. J. Mol. Sci. 2017, 18(3), 681; doi:10.3390/ijms18030681

Anti-Obesity Effect of Bombus ignitus Queen Glycosaminoglycans in Rats on a High-Fat Diet

1
Department of Agricultural Biology, National Academy of Agricultural Science, Rural Development Administration (RDA), Wanju-Gun 55365, Korea
2
Pharmacogenechips Inc., Chuncheon 200-160, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Charles Brennan
Received: 12 January 2017 / Revised: 10 March 2017 / Accepted: 15 March 2017 / Published: 22 March 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

The mechanism of functional insect glycosaminoglycan (GAG) on obesity caused a high fat diet has not yet been elucidated. Therefore, insect glycosaminoglycans derived from Isaria sinclairii, Bombus ignitus (a type of bumblebee) queen, and Gryllus bimaculatus were purified and investigated as a potential functional food. 14-week old male Wistar rats were fed a high-fat diet (HFD) for 6 weeks. There were five groups that received daily intraperitoneal administration of phosphate buffered saline (PBS, control), GbG (GAG from Gryllus bimaculatus) 10 mg/kg, ISG (GAG from Isaria sinclairii) 10 mg/kg, IQG (GAG from Bombus ignites) 10 mg/kg, or Pravastatin (2 mg/kg). All treatments were performed for one month. IQG produced a potential anti-inflammatory effect with the inhibition of c-reactive protein and sero-biochemical parameters of phospholipids and free fatty acids indicative of an anti-hyperlipidemic effect. Abdominal and epididymidal fat weight were reduced in conjunction with a mild increase in body weight. The level of laminin in HMVEC-C cells or fibronectin in HFD rat hepatocytes was significantly affected by these GAG treatments, which regulated adipogenesis and adipocyte function. Compared to the control rats, IQG-treated rats displayed up-regulation of 87 genes (test:control ratio >2.0) including fatty acid synthase and 3-hydroxy-3-methylglutaryl-coenzyme A reductase, with the down-regulation of 47 genes including the uridine diphosphate (UDP) glycosyltransferase 2 families, polypeptidase B, and insulin-like growth factor binding protein 1. The data suggest that IQG could potentially prevent or treat fatty liver or hyperlipidemia. View Full-Text
Keywords: anti-obesity effect; glycosaminoglycan from bumblebee (queen of Bumbus ignitus); high fat dieted rat anti-obesity effect; glycosaminoglycan from bumblebee (queen of Bumbus ignitus); high fat dieted rat
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MDPI and ACS Style

Ahn, M.Y.; Kim, B.J.; Kim, H.J.; Yoon, H.J.; Jee, S.D.; Hwang, J.S.; Park, K.-K. Anti-Obesity Effect of Bombus ignitus Queen Glycosaminoglycans in Rats on a High-Fat Diet. Int. J. Mol. Sci. 2017, 18, 681.

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