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Int. J. Mol. Sci. 2017, 18(10), 2195; https://doi.org/10.3390/ijms18102195

Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification

Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan
Received: 22 August 2017 / Revised: 14 October 2017 / Accepted: 17 October 2017 / Published: 20 October 2017
(This article belongs to the Collection Advances in Molecular Oncology)
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Abstract

Accumulating evidence suggests that renal cell tumors represent a group of histologically and molecularly heterogeneous diseases, even within the same histological subtype. In accordance with the increased understanding of the morphological, immunohistochemical, molecular, and epidemiological characteristics of renal cell tumors, the World Health Organization (WHO) classification of renal cell tumors has been modified. This review provides perspectives on both new and current subtypes of renal cell tumors, as well as on the emerging/provisional renal cell carcinomas in the new 2016 WHO classification, which focuses on features of their molecular pathological epidemiology. The WHO classification will require additional revisions to enable the classification of renal cell tumors as clinically meaningful subtypes and provide a better understanding of the unique characteristics of renal cell tumors. View Full-Text
Keywords: histology; immunohistochemistry; kidney; genetic alteration; molecular pathology; renal cell carcinoma histology; immunohistochemistry; kidney; genetic alteration; molecular pathology; renal cell carcinoma
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Inamura, K. Renal Cell Tumors: Understanding Their Molecular Pathological Epidemiology and the 2016 WHO Classification. Int. J. Mol. Sci. 2017, 18, 2195.

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