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Int. J. Mol. Sci. 2017, 18(10), 2079; doi:10.3390/ijms18102079

The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression

1
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
2
Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 10617, Taiwan
*
Author to whom correspondence should be addressed.
Received: 23 August 2017 / Revised: 21 September 2017 / Accepted: 27 September 2017 / Published: 30 September 2017
(This article belongs to the Special Issue Molecular Research on Urology)
View Full-Text   |   Download PDF [572 KB, uploaded 30 September 2017]   |  

Abstract

In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes the beginning of the end disease, which eventually leads to cancer death. Many mechanisms have been identified in this process that can be rationalized into targeted therapy. Among them, epithelial-to-mesenchymal transition (EMT) is originally characterized as a critical step for cell trans-differentiation during embryo development and now recognized in promoting cancer cells invasiveness because of high mobility and migratory abilities of mesenchymal cells once converted from carcinoma cells. Nevertheless, the underlying pathways leading to EMT appear to be very diverse in different cancer types, which certainly represent a challenge for developing effective intervention. In this article, we have carefully reviewed the key factors involved in EMT of PCa with clinical correlation in hope to facilitate the development of new therapeutic strategy that is expected to reduce the disease mortality. View Full-Text
Keywords: epithelial-to-mesenchymal transition; metastasis; prostate cancer progression epithelial-to-mesenchymal transition; metastasis; prostate cancer progression
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Lo, U.-G.; Lee, C.-F.; Lee, M.-S.; Hsieh, J.-T. The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression. Int. J. Mol. Sci. 2017, 18, 2079.

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