Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite
AbstractThe aims of this study were to: (1) synthesize an anti-biofilm and protein-repellent dental composite by combining 2-methacryloyloxyethyl phosphorylcholine (MPC) with quaternary ammonium dimethylaminohexadecyl methacrylate (DMAHDM); and (2) evaluate the effects of water-aging for 180 days on protein resistance, bacteria-killing ability, and mechanical properties of MPC-DMAHDM composite. MPC and DMAHDM were added into a resin composite. Specimens were stored in distilled water at 37 °C for 1, 30, 90, and 180 days. Mechanical properties were measured in three-point flexure. Protein attachment onto the composite was evaluated by a micro bicinchoninic acid approach. An oral plaque microcosm biofilm model was employed to evaluate oral biofilm viability vs. water-aging time. Mechanical properties of the MPC-DMAHDM composite after 180-day immersion matched those of the commercial control composite. The composite with 3% MPC + 1.5% DMAHDM had much stronger resistance to protein adhesion than control (p < 0.05). MPC + DMAHDM achieved much stronger biofilm-eradicating effects than MPC or DMAHDM alone (p < 0.05). Biofilm colony-forming units on the 3% MPC + 1.5% DMAHDM composite were three orders of magnitude lower than commercial control. The protein-repellent and antibacterial effects were durable and showed no loss in water-aging from 1 to 180 days. The novel MPC-DMAHDM composite possessed strong and durable resistance to protein adhesion and potent bacteria-eradicating function, while matching the load-bearing ability of a commercial dental composite. The novel MPC-DMAHDM composite represents a promising means of suppressing oral plaque growth, acid production, and secondary caries. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Zhang, N.; Zhang, K.; Melo, M.A.S.; Weir, M.D.; Xu, D.J.; Bai, Y.; Xu, H.H.K. Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite. Int. J. Mol. Sci. 2017, 18, 186.
Zhang N, Zhang K, Melo MAS, Weir MD, Xu DJ, Bai Y, Xu HHK. Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite. International Journal of Molecular Sciences. 2017; 18(1):186.Chicago/Turabian Style
Zhang, Ning; Zhang, Ke; Melo, Mary A.S.; Weir, Michael D.; Xu, David J.; Bai, Yuxing; Xu, Hockin H.K. 2017. "Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite." Int. J. Mol. Sci. 18, no. 1: 186.