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Int. J. Mol. Sci. 2017, 18(1), 186; doi:10.3390/ijms18010186

Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite

1
Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China
2
Department of Endodontics, Periodontics and Prosthodontics, University of Maryland Dental School, Baltimore, MD 21201, USA
3
Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
4
Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
5
Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Antonella Piozzi
Received: 28 November 2016 / Revised: 4 January 2017 / Accepted: 10 January 2017 / Published: 18 January 2017
(This article belongs to the Section Biomaterial Sciences)
View Full-Text   |   Download PDF [4267 KB, uploaded 18 January 2017]   |  

Abstract

The aims of this study were to: (1) synthesize an anti-biofilm and protein-repellent dental composite by combining 2-methacryloyloxyethyl phosphorylcholine (MPC) with quaternary ammonium dimethylaminohexadecyl methacrylate (DMAHDM); and (2) evaluate the effects of water-aging for 180 days on protein resistance, bacteria-killing ability, and mechanical properties of MPC-DMAHDM composite. MPC and DMAHDM were added into a resin composite. Specimens were stored in distilled water at 37 °C for 1, 30, 90, and 180 days. Mechanical properties were measured in three-point flexure. Protein attachment onto the composite was evaluated by a micro bicinchoninic acid approach. An oral plaque microcosm biofilm model was employed to evaluate oral biofilm viability vs. water-aging time. Mechanical properties of the MPC-DMAHDM composite after 180-day immersion matched those of the commercial control composite. The composite with 3% MPC + 1.5% DMAHDM had much stronger resistance to protein adhesion than control (p < 0.05). MPC + DMAHDM achieved much stronger biofilm-eradicating effects than MPC or DMAHDM alone (p < 0.05). Biofilm colony-forming units on the 3% MPC + 1.5% DMAHDM composite were three orders of magnitude lower than commercial control. The protein-repellent and antibacterial effects were durable and showed no loss in water-aging from 1 to 180 days. The novel MPC-DMAHDM composite possessed strong and durable resistance to protein adhesion and potent bacteria-eradicating function, while matching the load-bearing ability of a commercial dental composite. The novel MPC-DMAHDM composite represents a promising means of suppressing oral plaque growth, acid production, and secondary caries. View Full-Text
Keywords: dental composite; protein repellent; antibacterial; long-term durability; water-aging; caries inhibition dental composite; protein repellent; antibacterial; long-term durability; water-aging; caries inhibition
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MDPI and ACS Style

Zhang, N.; Zhang, K.; Melo, M.A.S.; Weir, M.D.; Xu, D.J.; Bai, Y.; Xu, H.H.K. Effects of Long-Term Water-Aging on Novel Anti-Biofilm and Protein-Repellent Dental Composite. Int. J. Mol. Sci. 2017, 18, 186.

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