Bone Niches, Hematopoietic Stem Cells, and Vessel Formation
AbstractBone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely controlled by numerous signals emerging from the bone marrow niches where HSCs reside. This review will focus on the description of the role of BM niches in the control of the fate of HSCs and will also highlight the role of the BM niches in the regulation of vasculogenesis and angiogenesis. Moreover, alterations of the signals in niche microenvironment are involved in many aspects of tumor progression and vascularization and further knowledge could provide the basis for the development of new therapeutic strategies. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Tamma, R.; Ribatti, D. Bone Niches, Hematopoietic Stem Cells, and Vessel Formation. Int. J. Mol. Sci. 2017, 18, 151.
Tamma R, Ribatti D. Bone Niches, Hematopoietic Stem Cells, and Vessel Formation. International Journal of Molecular Sciences. 2017; 18(1):151.Chicago/Turabian Style
Tamma, Roberto; Ribatti, Domenico. 2017. "Bone Niches, Hematopoietic Stem Cells, and Vessel Formation." Int. J. Mol. Sci. 18, no. 1: 151.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.