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Int. J. Mol. Sci. 2017, 18(1), 140; doi:10.3390/ijms18010140

Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress

Department of Pharmacy, University of Naples “Federico II”, 80131 Naples, Italy
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Authors to whom correspondence should be addressed.
Academic Editor: Constantinos Stathopoulos
Received: 30 September 2016 / Revised: 12 December 2016 / Accepted: 5 January 2017 / Published: 12 January 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The nucleolus is the site of ribosome biogenesis, a complex process that requires the coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that participate in the maturation of ribosomal RNA (rRNA) and assembly of small and large subunits. Nevertheless, emerging studies have highlighted the fundamental role of the nucleolus in sensing a variety of cellular stress stimuli that target ribosome biogenesis. This condition is known as nucleolar stress and triggers several response pathways to maintain cell homeostasis, either p53-dependent or p53-independent. The mouse double minute (MDM2)-p53 stress signaling pathways are activated by multiple signals and are among the most important regulators of cellular homeostasis. In this review, we will focus on the role of ribosomal proteins in p53-dependent and p53-independent response to nucleolar stress considering novel identified regulators of these pathways. We describe, in particular, the role of ribosomal protein uL3 (rpL3) in p53-independent nucleolar stress signaling pathways. View Full-Text
Keywords: nucleolar stress; p53; uL3 (rpL3); apoptosis; ribosomal proteins; ribosome; nucleolus nucleolar stress; p53; uL3 (rpL3); apoptosis; ribosomal proteins; ribosome; nucleolus
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Russo, A.; Russo, G. Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress. Int. J. Mol. Sci. 2017, 18, 140.

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