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Int. J. Mol. Sci. 2017, 18(1), 124; doi:10.3390/ijms18010124

Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit

1
Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Katraj, Pune, Maharashtra 411043, India
2
Department of Pathology, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, Maharashtra 411043, India
3
Department of Pharmacology, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth Deemed University, Pune-Satara Road, Pune, Maharashtra 411043, India
4
School of Science, RMIT University, Melbourne 3000, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 7 November 2016 / Revised: 24 December 2016 / Accepted: 28 December 2016 / Published: 11 January 2017
View Full-Text   |   Download PDF [4730 KB, uploaded 11 January 2017]   |  

Abstract

The study was designed to assess the effect of different strawberry extracts on glucose levels, lipid profiles, and oxidative stress in nicotinamide-streptozotocin (NIC-STZ) induced diabetic rats. The associated changes were evaluated through biochemical, molecular, and histological assays. Diabetes was induced by intraperitoneal injection of STZ to albino Wistar rats after treatment with nicotinamide. Aqueous, hydroalcoholic, and alcoholic strawberry extracts were administrated orally to diabetic rats. Treatment of strawberry extracts improved lipid profile, liver function, and serum creatinine and led to a significant increase in antioxidant status in diabetic rats. Real-time PCR expression analysis of genes from the liver of animals treated with strawberry extracts exhibited downregulation of several fatty acid synthesis genes, transcription factors, such as Sterol regulatory Element Binding Transcription factor (SREBP) and Nuclear Factor-κβ (NF-κβ), and inflammatory markers, like Interleukin 6 (IL6) and Tumor Necrosis Factor-α (TNF-α). Strawberry extracts also upregulated liver Peroxisome Proliferator Activated Receptor-γ (PPAR-γ). Histological examination confirmed the nephroprotective and β-cell regeneration/protection effects of strawberry extracts. The present study demonstrates several beneficial effects of strawberry extracts along with its probable mechanism of action. View Full-Text
Keywords: β-cell regeneration/protection effects; antihyperglycemic activity; normolipidemic activity; oxidative stress; strawberry β-cell regeneration/protection effects; antihyperglycemic activity; normolipidemic activity; oxidative stress; strawberry
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MDPI and ACS Style

Mandave, P.; Khadke, S.; Karandikar, M.; Pandit, V.; Ranjekar, P.; Kuvalekar, A.; Mantri, N. Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit. Int. J. Mol. Sci. 2017, 18, 124.

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