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Int. J. Mol. Sci. 2017, 18(1), 115; doi:10.3390/ijms18010115

Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program

Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
Technology Convergence R&D Group, Korea Institute of Industrial Technology, Yeongcheon 770-200, Korea
Department of New Drug Discovery and Development, Chungnam National University, Daejon 305-764, Korea
College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
Department of Physiology, College of Medicine, Yeungnam University, 42415, Korea
Theses authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Julian Borejdo
Received: 1 October 2016 / Revised: 22 December 2016 / Accepted: 3 January 2017 / Published: 8 January 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Irregularities in the cellular uptake of thyroid hormones significantly affect muscle development and regeneration. Herein, we report indispensable role of transthyretin (TTR) in maintaining cellular thyroxine level. TTR was found to enhance recruitment of muscle satellite cells to the site of injury, thereby regulating muscle regeneration. Fluorescence-activated cell sorting (FACS) and immunofluorescence analysis of TTRwt (TTR wild type) and TTRkd (TTR knock-down) cells revealed that TTR controlled cell cycle progression by affecting the expression of Cyclin A2. Deiodinase 2 (D2) mediated increases in triiodothyronine levels were found to regulate the expression of myogenic marker, myogenin (MYOG). Moreover, use of a coumarin derivative (CD) revealed a significant reduction in cellular thyroxine, thereby indicating that TTR play a role in the transport of thyroxine. Taken together, these findings suggest that TTR mediated transport of thyroxine represents a survival mechanism necessary for the myogenic program. The results of this study will be highly useful to the strategic development of novel therapeutics to combat muscular dystrophies. View Full-Text
Keywords: myoblast; transthyretin; proliferation; differentiation myoblast; transthyretin; proliferation; differentiation

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Lee, E.J.; Pokharel, S.; Jan, A.T.; Huh, S.; Galope, R.; Lim, J.H.; Lee, D.-M.; Choi, S.W.; Nahm, S.-S.; Kim, Y.-W.; Park, S.-Y.; Choi, I. Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program. Int. J. Mol. Sci. 2017, 18, 115.

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