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Int. J. Mol. Sci. 2016, 17(9), 1583; doi:10.3390/ijms17091583

Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD)

1
Philip Morris International Research and Development, Philip Morris Products S.A. (Part of Philip Morris International Group of Companies), Quai Jeanrenaud 5, 2000 Neuchatel, Switzerland
2
Zora Biosciences Oy, 02150 Espoo, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Guido R. M. M. Haenen
Received: 14 July 2016 / Revised: 6 September 2016 / Accepted: 13 September 2016 / Published: 20 September 2016
(This article belongs to the Section Molecular Toxicology)
View Full-Text   |   Download PDF [1761 KB, uploaded 20 September 2016]   |  

Abstract

Smoking is a major risk factor for several diseases including chronic obstructive pulmonary disease (COPD). To better understand the systemic effects of cigarette smoke exposure and mild to moderate COPD—and to support future biomarker development—we profiled the serum lipidomes of healthy smokers, smokers with mild to moderate COPD (GOLD stages 1 and 2), former smokers, and never-smokers (n = 40 per group) (ClinicalTrials.gov registration: NCT01780298). Serum lipidome profiling was conducted with untargeted and targeted mass spectrometry-based lipidomics. Guided by weighted lipid co-expression network analysis, we identified three main trends comparing smokers, especially those with COPD, with non-smokers: a general increase in glycero(phospho)lipids, including triglycerols; changes in fatty acid desaturation (decrease in ω-3 polyunsaturated fatty acids, and an increase in monounsaturated fatty acids); and an imbalance in eicosanoids (increase in 11,12- and 14,15-DHETs (dihydroxyeicosatrienoic acids), and a decrease in 9- and 13-HODEs (hydroxyoctadecadienoic acids)). The lipidome profiles supported classification of study subjects as smokers or non-smokers, but were not sufficient to distinguish between smokers with and without COPD. Overall, our study yielded further insights into the complex interplay between smoke exposure, lung disease, and systemic alterations in serum lipid profiles. View Full-Text
Keywords: lipidomics; tobacco smoke; clinical study; chronic obstructive pulmonary disease; biomarker lipidomics; tobacco smoke; clinical study; chronic obstructive pulmonary disease; biomarker
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Titz, B.; Luettich, K.; Leroy, P.; Boue, S.; Vuillaume, G.; Vihervaara, T.; Ekroos, K.; Martin, F.; Peitsch, M.C.; Hoeng, J. Alterations in Serum Polyunsaturated Fatty Acids and Eicosanoids in Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD). Int. J. Mol. Sci. 2016, 17, 1583.

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