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Int. J. Mol. Sci. 2016, 17(9), 1585; doi:10.3390/ijms17091585

Protein Kinases and Parkinson’s Disease

1
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA
3
Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Katalin Prokai-Tatrai
Received: 30 May 2016 / Revised: 9 August 2016 / Accepted: 1 September 2016 / Published: 20 September 2016
(This article belongs to the Special Issue Neuroprotective Strategies 2016)
View Full-Text   |   Download PDF [597 KB, uploaded 20 September 2016]   |  

Abstract

Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson’s disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson’s disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson’s disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules. View Full-Text
Keywords: Parkinson’s disease; dopamine; tyrosine kinase; serine/threonine kinase; kinase inhibitors Parkinson’s disease; dopamine; tyrosine kinase; serine/threonine kinase; kinase inhibitors
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Mehdi, S.J.; Rosas-Hernandez, H.; Cuevas, E.; Lantz, S.M.; Barger, S.W.; Sarkar, S.; Paule, M.G.; Ali, S.F.; Imam, S.Z. Protein Kinases and Parkinson’s Disease. Int. J. Mol. Sci. 2016, 17, 1585.

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