Testosterone-Mediated Endocrine Function and TH1/TH2 Cytokine Balance after Prenatal Exposure to Perfluorooctane Sulfonate: By Sex Status
AbstractLittle information exists about the evaluation of potential developmental immunotoxicity induced by perfluorooctane sulfonate (PFOS), a synthetic persistent and increasingly ubiquitous environmental contaminant. To assess potential sex-specific impacts of PFOS on immunological health in the offspring, using male and female C57BL/6 mice, pups were evaluated for developmental immunotoxic effects after maternal oral exposure to PFOS (0.1, 1.0 and 5.0 mg PFOS/kg/day) during Gestational Days 1–17. Spontaneous TH1/TH2-type cytokines, serum levels of testosterone and estradiol were evaluated in F1 pups at four and eight weeks of age. The study showed that male pups were more sensitive to the effects of PFOS than female pups. At eight weeks of age, an imbalance in TH1/TH2-type cytokines with excess TH2 cytokines (IL-4) was found only in male pups. As for hormone levels, PFOS treatment in utero significantly decreased serum testosterone levels and increased estradiol levels only in male pups, and a significant interaction between sex and PFOS was observed for serum testosterone at both four weeks of age (pinteraction = 0.0049) and eight weeks of age (pinteraction = 0.0227) and for estradiol alternation at four weeks of age (pinteraction = 0.0351). In conclusion, testosterone-mediated endocrine function may be partially involved in the TH1/TH2 imbalance induced by PFOS, and these deficits are detectable among both young and adult mice and may affect males more than females. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Zhong, S.-Q.; Chen, Z.-X.; Kong, M.-L.; Xie, Y.-Q.; Zhou, Y.; Qin, X.-D.; Paul, G.; Zeng, X.-W.; Dong, G.-H. Testosterone-Mediated Endocrine Function and TH1/TH2 Cytokine Balance after Prenatal Exposure to Perfluorooctane Sulfonate: By Sex Status. Int. J. Mol. Sci. 2016, 17, 1509.
Zhong S-Q, Chen Z-X, Kong M-L, Xie Y-Q, Zhou Y, Qin X-D, Paul G, Zeng X-W, Dong G-H. Testosterone-Mediated Endocrine Function and TH1/TH2 Cytokine Balance after Prenatal Exposure to Perfluorooctane Sulfonate: By Sex Status. International Journal of Molecular Sciences. 2016; 17(9):1509.Chicago/Turabian Style
Zhong, Shou-Qiang; Chen, Zan-Xiong; Kong, Min-Li; Xie, Yan-Qi; Zhou, Yang; Qin, Xiao-Di; Paul, Gunther; Zeng, Xiao-Wen; Dong, Guang-Hui. 2016. "Testosterone-Mediated Endocrine Function and TH1/TH2 Cytokine Balance after Prenatal Exposure to Perfluorooctane Sulfonate: By Sex Status." Int. J. Mol. Sci. 17, no. 9: 1509.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.