Next Article in Journal
Inflammaging and Frailty Status Do Not Result in an Increased Extracellular Vesicle Concentration in Circulation
Next Article in Special Issue
The Effects of Aquaporin-1 in Pulmonary Edema Induced by Fat Embolism Syndrome
Previous Article in Journal
Immune Checkpoint Inhibitors: A New Opportunity in the Treatment of Ovarian Cancer?
Previous Article in Special Issue
Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(7), 1172; doi:10.3390/ijms17071172

Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation

Department of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 25 May 2016 / Revised: 12 July 2016 / Accepted: 14 July 2016 / Published: 20 July 2016
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [3299 KB, uploaded 20 July 2016]   |  

Abstract

Aquaporins (AQPs) play important roles in the water transport system in the human body. There are currently 13 types of AQP, AQP0 through AQP12, which are expressed in various organs. Many members of the AQP family are expressed in the intestinal tract. AQP3 is predominantly expressed in the colon, ultimately controlling the water transport. Recently, it was clarified that several laxatives exhibit a laxative effect by changing the AQP3 expression level in the colon. In addition, it was revealed that morphine causes severe constipation by increasing the AQP3 expression level in the colon. These findings have shown that AQP3 is one of the most important functional molecules in water transport in the colon. This review will focus on the physiological and pathological roles of AQP3 in the colon, and discuss clinical applications of colon AQP3. View Full-Text
Keywords: aquaporin; colon; diarrhea; laxative; constipation; morphine aquaporin; colon; diarrhea; laxative; constipation; morphine
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ikarashi, N.; Kon, R.; Sugiyama, K. Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation. Int. J. Mol. Sci. 2016, 17, 1172.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top