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Int. J. Mol. Sci. 2016, 17(4), 548; doi:10.3390/ijms17040548

Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD

Department of Pathophysiology and Transplantation, IRCCS “Ca’ Granda” IRCCS Foundation, Poiliclinico Hospital, University of Milan, Centro delle Malattie Metaboliche del Fegato, Milan 20122, Italy
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Academic Editors: Amedeo Lonardo and Giovanni Targher
Received: 3 March 2016 / Revised: 1 April 2016 / Accepted: 5 April 2016 / Published: 12 April 2016
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research 2016)
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Abstract

Nonalcoholic fatty liver disease (NAFLD), tightly linked to the metabolic syndrome (MS), has emerged as a leading cause of chronic liver disease worldwide. Since it is potentially progressive towards non-alcoholic steatohepatitis (NASH) and hepatic fibrosis, up to cirrhosis and its associated complications, the need for predictive factors of NAFLD and of its advanced forms is mandatory. Despite the current “gold standard” for the assessment of liver damage in NAFLD being liver biopsy, in recent years, several non-invasive tools have been designed as alternatives to histology, of which fibroscan seems the most promising. Among the different serum markers considered, serum uric acid (SUA) and ferritin have emerged as possible predictors of severity of liver damage in NAFLD. In fact, as widely described in this review, they share common pathogenetic pathways and are both associated with hepatic steatosis and MS, thus suggesting a likely synergistic action. Nevertheless, the power of these serum markers seems to be too low if considered alone, suggesting that they should be included in a wider perspective together with other metabolic and biochemical parameters in order to predict liver damage. View Full-Text
Keywords: SUA; liver damage; fibrosis; NASH; serum markers; oxidative stress; insulin resistance; metabolic syndrome SUA; liver damage; fibrosis; NASH; serum markers; oxidative stress; insulin resistance; metabolic syndrome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lombardi, R.; Pisano, G.; Fargion, S. Role of Serum Uric Acid and Ferritin in the Development and Progression of NAFLD. Int. J. Mol. Sci. 2016, 17, 548.

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