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Int. J. Mol. Sci. 2016, 17(4), 457; doi:10.3390/ijms17040457

Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk

1
Department of Epidemiology, School of Medicine, Jinan University, Guangzhou 510632, China
2
Department of Stomatology of the First Affiliated Hospital of Jinan University, Guangzhou 510632, China
3
Department of Parasitology, School of Medicine, Jinan University, Guangzhou 510632, China
4
Key Laboratory of Environmental Exposure and Health in Guangzhou, Jinan University, Guangzhou 510632, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Emil Alexov
Received: 16 February 2016 / Revised: 17 March 2016 / Accepted: 17 March 2016 / Published: 30 March 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

The pathogenesis of celiac disease (CD) has been related to polymorphisms in the regulator of G-protein signaling 1 (RGS1) and interleukin-12 A (IL12A) genes, but the existing findings are inconsistent. Our aim is to investigate the associations of two single-nucleotide polymorphisms (SNPs) (rs2816316 in RGS1 and rs17810546 in IL12A) with CD risk using meta-analysis. We searched PubMed and Web of Science on RGS1 rs2816316 and IL12A rs17810546 with CD risk. Odds ratio (OR) and 95% confidence interval (CI) of each SNP were estimated. All statistical analyses were performed on Stata 12.0. A total of seven studies were retrieved and analyzed. The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74–0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31–1.43). The co-dominant model of genotype effect confirmed the significant associations between RGS1 rs2816316/IL12A rs17810546 and CD. No evidence of publication bias was observed. Our meta-analysis supports the associations of RGS1 and IL12A with CD and strongly calls for further studies to better understand the roles of RGS1 and IL12A in the pathogenesis of CD. View Full-Text
Keywords: celiac disease; IL12A; meta-analysis; polymorphism; RGS1 celiac disease; IL12A; meta-analysis; polymorphism; RGS1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Guo, C.-C.; Wang, M.; Cao, F.-D.; Huang, W.-H.; Xiao, D.; Ye, X.-G.; Ou, M.-L.; Zhang, N.; Zhang, B.-H.; Liu, Y.; Yang, G.; Jing, C.-X. Meta-Analysis on Associations of RGS1 and IL12A Polymorphisms with Celiac Disease Risk. Int. J. Mol. Sci. 2016, 17, 457.

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