LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression
Abstract
:1. Fibrotic Diseases
2. Type I Collagen
3. Posttranscriptional Regulation of Expression of Type I Collagen
4. LARP6 Is the Specific RNA Binding Protein of Collagen mRNAs
5. Role of LARP6 Binding in Fibrosis Development
6. Stabilization of Collagen mRNAs by Interaction of LARP6 and Vimentin Filaments
7. Unique Aspects of Translation of Collagen mRNAs
8. Coordinated Translation of Collagen mRNAs Is Regulated by Interaction of LARP6 and Serine Threonine Kinase Receptor Associated Protein (STRAP)
9. RNA Helicase A Increases Translational Competitiveness of Collagen mRNA
10. Interaction of LARP6 and FKBP3 Increases the Half-Life of LARP6
11. Phosphorylation of LARP6 Regulates Its Activity in Fibrosis
12. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
LARP6 | La ribonucleoproteins domain family, member 6 |
ER | endoplasmic reticulum |
HSC | hepatic stellate cell |
TGF-β | transforming growth factor β |
RRM | RNA recognition motif |
nt | nucleotides |
LOX | 15-lipoxygenase |
ORF | open reading frame |
UNRIP | upstream of N-ras interacting protein |
STRAP | serine threonine kinase receptor associated protein |
RHA | RNA helicase A |
PCE | posttranscriptional control element |
FKBP25/FKBP3 | 25 kD FK506 binding protein |
PPIase | cis-trans prolyl isomerase |
CTER | C-terminal of domain |
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Zhang, Y.; Stefanovic, B. LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. Int. J. Mol. Sci. 2016, 17, 419. https://doi.org/10.3390/ijms17030419
Zhang Y, Stefanovic B. LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression. International Journal of Molecular Sciences. 2016; 17(3):419. https://doi.org/10.3390/ijms17030419
Chicago/Turabian StyleZhang, Yujie, and Branko Stefanovic. 2016. "LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression" International Journal of Molecular Sciences 17, no. 3: 419. https://doi.org/10.3390/ijms17030419