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Int. J. Mol. Sci. 2016, 17(1), 31; doi:10.3390/ijms17010031

RNA Binding Proteins in the miRNA Pathway

1
Faculty of Science 1, University of Technology, Sydney, NSW 2007, Australia
2
Faculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, Australia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kotb Abdelmohsen
Received: 9 November 2015 / Revised: 13 December 2015 / Accepted: 23 December 2015 / Published: 26 December 2015
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
View Full-Text   |   Download PDF [1401 KB, uploaded 26 December 2015]   |  

Abstract

microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets. View Full-Text
Keywords: miRNA; RNA binding protein; Drosha; Dicer; Argonaute; cross-linking and immonoprecipitation (CLIP) miRNA; RNA binding protein; Drosha; Dicer; Argonaute; cross-linking and immonoprecipitation (CLIP)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Connerty, P.; Ahadi, A.; Hutvagner, G. RNA Binding Proteins in the miRNA Pathway. Int. J. Mol. Sci. 2016, 17, 31.

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