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Int. J. Mol. Sci. 2016, 17(2), 228; doi:10.3390/ijms17020228

Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis

1,†
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2,†
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1,†
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1
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1
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2
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1,* and 3,*
1
School of Basic Medical & Nursing School, Chengdu University, Chengdu 610106, China
2
School of Life Sciences and Key Laboratory of Bio-resources, Ministry of Education, Sichuan University, Chengdu 610064, China
3
School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 December 2015 / Revised: 30 January 2016 / Accepted: 2 February 2016 / Published: 8 February 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2324 KB, uploaded 18 February 2016]   |  

Abstract

Plant lectins have been investigated to elucidate their complicated mechanisms due to their remarkable anticancer activities. Although plant lectins seems promising as a potential anticancer agent for further preclinical and clinical uses, further research is still urgently needed and should include more focus on molecular mechanisms. Herein, a Naïve Bayesian model was developed to predict the protein-protein interaction (PPI), and thus construct the global human PPI network. Moreover, multiple sources of biological data, such as smallest shared biological process (SSBP), domain-domain interaction (DDI), gene co-expression profiles and cross-species interolog mapping were integrated to build the core apoptotic PPI network. In addition, we further modified it into a plant lectin-induced apoptotic cell death context. Then, we identified 22 apoptotic hub proteins in mesothelioma cells according to their different microarray expressions. Subsequently, we used combinational methods to predict microRNAs (miRNAs) which could negatively regulate the abovementioned hub proteins. Together, we demonstrated the ability of our Naïve Bayesian model-based network for identifying novel plant lectin-treated cancer cell apoptotic pathways. These findings may provide new clues concerning plant lectins as potential apoptotic inducers for cancer drug discovery. View Full-Text
Keywords: plant lectin; apoptosis; Naïve Bayesian model; novel pathways; cancer plant lectin; apoptosis; Naïve Bayesian model; novel pathways; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shi, Z.; Sun, R.; Yu, T.; Liu, R.; Cheng, L.-J.; Bao, J.-K.; Zou, L.; Tang, Y. Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis. Int. J. Mol. Sci. 2016, 17, 228.

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