The Gas6/TAM System and Multiple Sclerosis
AbstractGrowth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS. View Full-Text
Share & Cite This Article
Bellan, M.; Pirisi, M.; Sainaghi, P.P. The Gas6/TAM System and Multiple Sclerosis. Int. J. Mol. Sci. 2016, 17, 1807.
Bellan M, Pirisi M, Sainaghi PP. The Gas6/TAM System and Multiple Sclerosis. International Journal of Molecular Sciences. 2016; 17(11):1807.Chicago/Turabian Style
Bellan, Mattia; Pirisi, Mario; Sainaghi, Pier P. 2016. "The Gas6/TAM System and Multiple Sclerosis." Int. J. Mol. Sci. 17, no. 11: 1807.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.