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Int. J. Mol. Sci. 2016, 17(10), 1616; doi:10.3390/ijms17101616

The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
2
South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-sen University, Guangzhou 510006, China
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Battino and Terrence Piva
Received: 1 August 2016 / Revised: 15 September 2016 / Accepted: 19 September 2016 / Published: 26 September 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. Syzygium samarangense and Passiflora edulis normalized various biochemical parameters. Solanum muricatum increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with Syzygium samarangense and Passiflora edulis could protect liver from the injury of alcohol, while Solanum muricatum could aggravate the damage. View Full-Text
Keywords: alcohol; liver injury; Syzygium samarangense; Passiflora edulis; Solanum muricatum alcohol; liver injury; Syzygium samarangense; Passiflora edulis; Solanum muricatum
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MDPI and ACS Style

Zhang, Y.-J.; Zhou, T.; Wang, F.; Zhou, Y.; Li, Y.; Zhang, J.-J.; Zheng, J.; Xu, D.-P.; Li, H.-B. The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury. Int. J. Mol. Sci. 2016, 17, 1616.

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