Next Article in Journal
Insights into Mechanisms of Chronic Neurodegeneration
Next Article in Special Issue
Molecular Neurobiology and Promising New Treatment in Depression
Previous Article in Journal
The Importance of Thrombin in Cerebral Injury and Disease
Previous Article in Special Issue
Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(1), 80; doi:10.3390/ijms17010080

Obesity and Its Potential Effects on Antidepressant Treatment Outcomes in Patients with Depressive Disorders: A Literature Review

1
Department of Psychiatry, College of Medicine, the Catholic University of Korea, Seoul 07345, Korea
2
Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON M5T 2S8, Canada
3
Department of Psychiatry, University of Toronto, Toronto, ON M5T 2S8, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 30 October 2015 / Accepted: 4 January 2016 / Published: 12 January 2016
View Full-Text   |   Download PDF [267 KB, uploaded 12 January 2016]

Abstract

Accumulating evidence regarding clinical, neurobiological, genetic, and environmental factors suggests a bidirectional link between obesity and depressive disorders. Although a few studies have investigated the link between obesity/excess body weight and the response to antidepressants in depressive disorders, the effect of weight on treatment response remains poorly understood. In this review, we summarized recent data regarding the relationship between the response to antidepressants and obesity/excess body weight in clinical studies of patients with depressive disorders. Although several studies indicated an association between obesity/excess body weight and poor antidepressant responses, it is difficult to draw definitive conclusions due to the variability of subject composition and methodological differences among studies. Especially, differences in sex, age and menopausal status, depressive symptom subtypes, and antidepressants administered may have caused inconsistencies in the results among studies. The relationship between obesity/excess body weight and antidepressant responses should be investigated further in high-powered studies addressing the differential effects on subject characteristics and treatment. Moreover, future research should focus on the roles of mediating factors, such as inflammatory markers and neurocognitive performance, which may alter the antidepressant treatment outcome in patients with comorbid obesity and depressive disorder. View Full-Text
Keywords: depressive disorder; obesity; antidepressant; response; treatment outcome depressive disorder; obesity; antidepressant; response; treatment outcome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Woo, Y.S.; Seo, H.-J.; McIntyre, R.S.; Bahk, W.-M. Obesity and Its Potential Effects on Antidepressant Treatment Outcomes in Patients with Depressive Disorders: A Literature Review. Int. J. Mol. Sci. 2016, 17, 80.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top