Next Article in Journal
Structure Prediction: New Insights into Decrypting Long Noncoding RNAs
Previous Article in Journal
Iron Homeostasis in Health and Disease
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(1), 134; doi:10.3390/ijms17010134

VLDL from Metabolic Syndrome Individuals Enhanced Lipid Accumulation in Atria with Association of Susceptibility to Atrial Fibrillation

1,2,3,4,5
,
1,4,5
,
4,5
,
1,4
,
1,4,5
,
1,3,4,5
,
1,3,4,5
,
3,4,5
,
4,5,6,7,8
,
1,2,3,* and 2,9,*
1
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
2
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
5
Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
6
Vascular and Medicinal Research, Texas Heart Institute, Houston, TX 77030, USA
7
New York Heart Research Foundation, Mineola, NY 11501, USA
8
Lipid and Glycoimmune Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
9
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Harry A. J. Struijker-Boudier
Received: 23 November 2015 / Revised: 29 December 2015 / Accepted: 15 January 2016 / Published: 20 January 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [2691 KB, uploaded 20 January 2016]   |  

Abstract

Metabolic syndrome (MetS) represents a cluster of metabolic derangements. Dyslipidemia is an important factor in MetS and is related to atrial fibrillation (AF). We hypothesized that very low density lipoproteins (VLDL) in MetS (MetS-VLDL) may induce atrial dilatation and vulnerability to AF. VLDL was therefore separated from normal (normal-VLDL) and MetS individuals. Wild type C57BL/6 male mice were divided into control, normal-VLDL (nVLDL), and MetS-VLDL (msVLDL) groups. VLDL (15 µg/g) and equivalent volumes of saline were injected via tail vein three times a week for six consecutive weeks. Cardiac chamber size and function were measured by echocardiography. MetS-VLDL significantly caused left atrial dilation (control, n = 10, 1.64 ± 0.23 mm; nVLDL, n = 7, 1.84 ± 0.13 mm; msVLDL, n = 10, 2.18 ± 0.24 mm; p < 0.0001) at week 6, associated with decreased ejection fraction (control, n = 10, 62.5% ± 7.7%, vs. msVLDL, n = 10, 52.9% ± 9.6%; p < 0.05). Isoproterenol-challenge experiment resulted in AF in young msVLDL mice. Unprovoked AF occurred only in elderly msVLDL mice. Immunohistochemistry showed excess lipid accumulation and apoptosis in msVLDL mice atria. These findings suggest a pivotal role of VLDL in AF pathogenesis for MetS individuals. View Full-Text
Keywords: atrial fibrillation; lipotoxicity; metabolic syndrome; very-low-density lipoprotein (VLDL) atrial fibrillation; lipotoxicity; metabolic syndrome; very-low-density lipoprotein (VLDL)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, H.-C.; Lin, H.-T.; Ke, L.-Y.; Wei, C.; Hsiao, Y.-L.; Chu, C.-S.; Lai, W.-T.; Shin, S.-J.; Chen, C.-H.; Sheu, S.-H.; Wu, B.-N. VLDL from Metabolic Syndrome Individuals Enhanced Lipid Accumulation in Atria with Association of Susceptibility to Atrial Fibrillation. Int. J. Mol. Sci. 2016, 17, 134.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top