Iron Homeostasis in Health and Disease
AbstractIron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress, and programmed cell death. The advance in understanding the main players and mechanisms involved in iron regulation significantly improved since the discovery of genes responsible for hemochromatosis, the IRE/IRPs machinery, and the hepcidin-ferroportin axis. This review provides an update on the molecular mechanisms regulating cellular and systemic Fe homeostasis and their roles in pathophysiologic conditions that involve alterations of iron metabolism, and provides novel therapeutic strategies to prevent the deleterious effect of its deficiency/overload. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Gozzelino, R.; Arosio, P. Iron Homeostasis in Health and Disease. Int. J. Mol. Sci. 2016, 17, 130.
Gozzelino R, Arosio P. Iron Homeostasis in Health and Disease. International Journal of Molecular Sciences. 2016; 17(1):130.Chicago/Turabian Style
Gozzelino, Raffaella; Arosio, Paolo. 2016. "Iron Homeostasis in Health and Disease." Int. J. Mol. Sci. 17, no. 1: 130.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.