Next Article in Journal
Drug Carrier for Photodynamic Cancer Therapy
Next Article in Special Issue
ω-3 Fatty Acids and Cardiovascular Diseases: Effects, Mechanisms and Dietary Relevance
Previous Article in Journal
Inhibition of Hepatocyte Apoptosis: An Important Mechanism of Corn Peptides Attenuating Liver Injury Induced by Ethanol
Previous Article in Special Issue
Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link?
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(9), 22081-22093; doi:10.3390/ijms160922081

Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats

1
EA 4489 Environnement Périnatal et Santé, Pôle Recherche Faculté de Médecine, Université Lille Nord de France, Lille 59045, France
2
Clinique de Chirurgie et Orthopédie de l'Enfant, Pôle Enfant, Hôpital Jeanne de Flandre, CHRU Lille, Lille 59037, France
3
Clinique de Néonatologie, Pôle Femme, Mère et Nouveau-Né, Hôpital Jeanne de Flandre, CHRU Lille, Lille 59037, France
4
Clinique de Gynécologie-Obstétrique, Pôle Femme, Mère et Nouveau-Né, Hôpital Jeanne de Flandre, CHRU Lille, Lille 59037, France
*
Author to whom correspondence should be addressed.
Academic Editors: Charles Brennan and Cenk Suphioglu
Received: 30 June 2015 / Revised: 27 July 2015 / Accepted: 7 September 2015 / Published: 14 September 2015
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Diseases)
View Full-Text   |   Download PDF [1501 KB, uploaded 14 September 2015]   |  

Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common complications of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids ω-3 (PUFA ω-3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA ω-3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia. Pregnant female Wistar rats (n = 14) were fed a control diet (n = 2), a PUFA ω-6 diet (n = 6), or a PUFA ω-3 diet (n = 6), starting with the 14th gestation day. At Day 1, female and newborn rats (10 per female) were exposed to hyperoxia (O2, n = 70) or to the ambient air (Air, n = 70). Six groups of newborns rats were obtained: PUFA ω-6/O2 (n = 30), PUFA ω-6/air (n = 30), PUFA ω-3/O2 (n = 30), PUFA ω-3/air (n = 30), control/O2 (n = 10), and control/air (n = 10). After 10 days, lungs were removed for analysis of alveolarization and pulmonary vascular development. Survival rate was 100%. Hyperoxia reduced alveolarization and increased pulmonary vascular wall thickness in both control (n = 20) and PUFA ω-6 groups (n = 60). Maternal PUFA ω-3 supplementation prevented the decrease in alveolarization caused by hyperoxia (n = 30) compared to PUFA ω-6/O2 (n = 30) or to the control/O2 (n = 10), but did not significantly increase the thickness of the lung vascular wall. Therefore, maternal PUFA ω-3 supplementation may protect newborn rats from lung injuries induced by hyperoxia. In clinical settings, maternal PUFA ω-3 supplementation during pregnancy and during lactation may prevent BPD development after premature birth. View Full-Text
Keywords: PUFA ω-3; bronchopulmonary dysplasia; prematurity; diet PUFA ω-3; bronchopulmonary dysplasia; prematurity; diet
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sharma, D.; Nkembi, A.S.; Aubry, E.; Houeijeh, A.; Butruille, L.; Houfflin-Debarge, V.; Besson, R.; Deruelle, P.; Storme, L. Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats. Int. J. Mol. Sci. 2015, 16, 22081-22093.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top