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Int. J. Mol. Sci. 2015, 16(8), 19989-20000; doi:10.3390/ijms160819989

Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link?

1
Department of Pediatrics, San Paolo Hospital, Department of Health Science, University of Milan, I-20142 Milan, Italy
2
Microbiology Unit, Department of Health Sciences, University of Milan, I-20142 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Cenk Suphioglu
Received: 13 June 2015 / Revised: 21 July 2015 / Accepted: 18 August 2015 / Published: 21 August 2015
(This article belongs to the Special Issue Omega-3 Fatty Acids in Health and Diseases)
View Full-Text   |   Download PDF [669 KB, uploaded 21 August 2015]

Abstract

Prevalence of metabolic syndrome is increasing in the pediatric population. Considering the different existing criteria to define metabolic syndrome, the use of the International Diabetes Federation (IDF) criteria has been suggested in children. Docosahexaenoic acid (DHA) has been associated with beneficial effects on health. The evidence about the relationship of DHA status in blood and components of the metabolic syndrome is unclear. This review discusses the possible association between DHA content in plasma and erythrocytes and components of the metabolic syndrome included in the IDF criteria (obesity, alteration of glucose metabolism, blood lipid profile, and blood pressure) and non-alcoholic fatty liver disease in obese children. The current evidence is inconsistent and no definitive conclusion can be drawn in the pediatric population. Well-designed longitudinal and powered trials need to clarify the possible association between blood DHA status and metabolic syndrome. View Full-Text
Keywords: metabolic syndrome; obesity; DHA; n-3 LCPUFA; glucose metabolism; lipid profile; blood pressure; NAFLD metabolic syndrome; obesity; DHA; n-3 LCPUFA; glucose metabolism; lipid profile; blood pressure; NAFLD
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lassandro, C.; Banderali, G.; Radaelli, G.; Borghi, E.; Moretti, F.; Verduci, E. Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link? Int. J. Mol. Sci. 2015, 16, 19989-20000.

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