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Int. J. Mol. Sci. 2015, 16(8), 17812-17825; doi:10.3390/ijms160817812

Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil

1
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
2
Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol 61615-585, Iran
3
Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol 61663-335, Iran
4
Pediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran 15468-15514, Iran
5
Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, Milan 20133, Italy
6
Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol, Zabol 98615-538, Iran
7
Department of Chemistry, Faculty of Science, University of Zabol, Zabol 98615-538, Iran
*
Authors to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 13 July 2015 / Revised: 27 July 2015 / Accepted: 28 July 2015 / Published: 3 August 2015
(This article belongs to the Special Issue Plant Molecular Biology)
View Full-Text   |   Download PDF [689 KB, uploaded 3 August 2015]   |  

Abstract

In this study, the essential oil (EO) constituents from the aerial parts of Satureja intermedia C.A.Mey were detected by GC and GC/MS. The antimicrobial activity of EO on oral pathogens and its cytotoxicity to human cancer cells were determined by the microbroth dilution method and the crystal violet staining method, respectively. Thirty-nine compounds were identified and the main EO constituents were γ-terpinene (37.1%), thymol (30.2%), p-cymene (16.2%), limonene (3.9%), α-terpinene (3.3%), myrcene (2.5%), germacrene B (1.4%), elemicine (1.1%) and carvacrol (0.5%). The S. intermedia EO showed a concentration-dependent decrease in viability of Hep-G2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) human cancer cell lines (p < 0.05). Antimicrobial screening of S. intermedia EO demonstrated slight antibacterial and antifungal activities against Streptococcus mutants, S. salivarius, Enterococcus faecalis, Staphylococcus aureus, Candida albicans and C. glabrata. Further preclinical studies are needed to assess the efficacy and safety of S. intermedia EO as a new promising anticancer agent. View Full-Text
Keywords: C/MS; oral pathogens; human cancer cells; hepatocellular carcinoma; breast adenocarcinoma C/MS; oral pathogens; human cancer cells; hepatocellular carcinoma; breast adenocarcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sharifi-Rad, J.; Sharifi-Rad, M.; Hoseini-Alfatemi, S.M.; Iriti, M.; Sharifi-Rad, M.; Sharifi-Rad, M. Composition, Cytotoxic and Antimicrobial Activities of Satureja intermedia C.A.Mey Essential Oil. Int. J. Mol. Sci. 2015, 16, 17812-17825.

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