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Int. J. Mol. Sci. 2015, 16(7), 16440-16453; doi:10.3390/ijms160716440

Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts

1
College of Life Sciences, Inner Mongolia University, Hohhot 010021, China
2
College of Basic Medical Science, Inner Mongolia Medical University, Hohhot 010110, China
3
Hulunbeir Municipal People's Hospital, Hailar 021008, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 9 February 2015 / Revised: 18 June 2015 / Accepted: 25 June 2015 / Published: 20 July 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1480 KB, uploaded 20 July 2015]   |  

Abstract

Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene that belongs to the ELOVL family and regulates the synthesis of very-long-chain fatty acids (VLCFAs) and sphingolipids, from yeast to mammals. Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell metabolism and is associated with fatty acids synthesis. In this study, we cloned the cDNA that encodes Cashmere goat (Capra hircus) ELOVL1 (GenBank Accession number KF549985) and investigated its expression in 10 tissues. ELOVL1 cDNA was 840 bp, encoding a deduced protein of 279 amino acids, and ELOVL1 mRNA was expressed in a wide range of tissues. Inhibition of mTORC1 by rapamycin decreased ELOVL1 expression and fatty acids synthesis in Cashmere goat fetal fibroblasts. These data show that ELOVL1 expression is regulated by mTORC1 and that mTORC1 has significant function in fatty acids synthesis in Cashmere goat. View Full-Text
Keywords: cashmere goat; ELOVL1; expression pattern cashmere goat; ELOVL1; expression pattern
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, W.; He, Q.; Guo, Z.; Yang, L.; Bao, L.; Bao, W.; Zheng, X.; Wang, Y.; Wang, Z. Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts. Int. J. Mol. Sci. 2015, 16, 16440-16453.

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