Next Article in Journal
Molecularly Imprinted Composite Membranes for Selective Detection of 2-Deoxyadenosine in Urine Samples
Next Article in Special Issue
Recombinant Lipases and Phospholipases and Their Use as Biocatalysts for Industrial Applications
Previous Article in Journal
Enzymatic Synthesis of Galactosylated Serine/Threonine Derivatives by β-Galactosidase from Escherichia coli
Previous Article in Special Issue
Enzymatic Polymerization on DNA Modified Gold Nanowire for Label-Free Detection of Pathogen DNA
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(6), 13729-13745; doi:10.3390/ijms160613729

Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production

Center for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, Ghent 9000, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 22 May 2015 / Accepted: 9 June 2015 / Published: 15 June 2015
(This article belongs to the Special Issue Molecular Biocatalysis)
View Full-Text   |   Download PDF [1739 KB, uploaded 15 June 2015]   |  

Abstract

Trehalose (α-d-glucopyranosyl α-d-glucopyranoside) is a non-reducing sugar with unique stabilizing properties due to its symmetrical, low energy structure consisting of two 1,1-anomerically bound glucose moieties. Many applications of this beneficial sugar have been reported in the novel food (nutricals), medical, pharmaceutical and cosmetic industries. Trehalose analogues, like lactotrehalose (α-d-glucopyranosyl α-d-galactopyranoside) or galactotrehalose (α-d-galactopyranosyl α-d-galactopyranoside), offer similar benefits as trehalose, but show additional features such as prebiotic or low-calorie sweetener due to their resistance against hydrolysis during digestion. Unfortunately, large-scale chemical production processes for trehalose analogues are not readily available at the moment due to the lack of efficient synthesis methods. Most of the procedures reported in literature suffer from low yields, elevated costs and are far from environmentally friendly. “Greener” alternatives found in the biocatalysis field, including galactosidases, trehalose phosphorylases and TreT-type trehalose synthases are suggested as primary candidates for trehalose analogue production instead. Significant progress has been made in the last decade to turn these into highly efficient biocatalysts and to broaden the variety of useful donor and acceptor sugars. In this review, we aim to provide an overview of the latest insights and future perspectives in trehalose analogue chemistry, applications and production pathways with emphasis on biocatalysis. View Full-Text
Keywords: prebiotic; galactosidase; glycosyltransferase; glycoside phosphorylase; enzyme engineering prebiotic; galactosidase; glycosyltransferase; glycoside phosphorylase; enzyme engineering
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Walmagh, M.; Zhao, R.; Desmet, T. Trehalose Analogues: Latest Insights in Properties and Biocatalytic Production. Int. J. Mol. Sci. 2015, 16, 13729-13745.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top