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Int. J. Mol. Sci. 2015, 16(6), 13287-13301; doi:10.3390/ijms160613287

Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL

1
Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany
2
Faculty of Engineering and Computer Science, Osnabrueck University of Applied Sciences, D-49076 Osnabrueck, Germany
3
Institute for Biomedical Engineering, Rostock University Medical Center, D-18119 Rostock, Germany
4
Materials and Processes Department, Laser Zentrum Hannover e.V., D-30419 Hannover, Germany
5
Institute for Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany
6
Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, D-30625 Hannover, Germany
7
Division of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, University of Rostock, D-18057 Rostock, Germany
8
Institut fuer Werkstoffkunde, Leibniz Universitaet Hannover, D-30823 Hannover, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander M. Seifalian
Received: 27 April 2015 / Accepted: 2 June 2015 / Published: 10 June 2015
(This article belongs to the Special Issue Artificial Organs)
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Abstract

Degradable implant material for bone remodeling that corresponds to the physiological stability of bone has still not been developed. Promising degradable materials with good mechanical properties are magnesium and magnesium alloys. However, excessive gas production due to corrosion can lower the biocompatibility. In the present study we used the polymer coating polycaprolactone (PCL), intended to lower the corrosion rate of magnesium. Additionally, improvement of implant geometry can increase bone remodeling. Porous structures are known to support vessel ingrowth and thus increase osseointegration. With the selective laser melting (SLM) process, defined open porous structures can be created. Recently, highly reactive magnesium has also been processed by SLM. We performed studies with a flat magnesium layer and with porous magnesium implants coated with polymers. The SLM produced magnesium was compared with the titanium alloy TiAl6V4, as titanium is already established for the SLM-process. For testing the biocompatibility, we used primary murine osteoblasts. Results showed a reduced corrosion rate and good biocompatibility of the SLM produced magnesium with PCL coating. View Full-Text
Keywords: titanium implant; magnesium implant; polycaprolactone; poly-3-hydroxybutyrate; live cell imaging; osteoblast titanium implant; magnesium implant; polycaprolactone; poly-3-hydroxybutyrate; live cell imaging; osteoblast
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Matena, J.; Petersen, S.; Gieseke, M.; Teske, M.; Beyerbach, M.; Kampmann, A.; Escobar, H.M.; Gellrich, N.-C.; Haferkamp, H.; Nolte, I. Comparison of Selective Laser Melted Titanium and Magnesium Implants Coated with PCL. Int. J. Mol. Sci. 2015, 16, 13287-13301.

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