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Int. J. Mol. Sci. 2015, 16(6), 12368-12381; doi:10.3390/ijms160612368

Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis

Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia 35100, Greece
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Academic Editors: Christoph Kleinschnitz and Sven Meuth
Received: 17 April 2015 / Revised: 22 May 2015 / Accepted: 27 May 2015 / Published: 1 June 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
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Abstract

CD24 is a cell-surface protein mainly expressed in cells of the immune and central nervous system (CNS), cells that play a critical role in the development of multiple sclerosis (MS). In the current study, we investigated four polymorphisms of the CD24 gene regarding their associations with MS. To this end, univariate and multivariate meta-analysis were applied along with modifications to include data from family-trios so as to increase the robustness of the meta-analysis. We found that the polymorphism 226 C>T (Ala57Val) of the CD24 gene is associated with MS according to the recessive mode of inheritance (odds ratio = 1.75; 95% CI: 1.09, 2.81). Moreover, the 1527–1528 TG>del polymorphism is inversely associated with MS according to the dominant mode of inheritance (odds ratio = 0.57; 95% CI 0.39, 0.83). Conversely, the 1056 A>G and 1626 A>G polymorphisms were not found to be associated with MS. We conclude that the CD24 226 C>T polymorphism increases the risk of MS, while the 1527–1528 TG>del polymorphism seems to have a protective role against MS, suggesting that these two polymorphisms can be used as predictive biomarkers for MS development. View Full-Text
Keywords: CD24; meta-analysis; multiple sclerosis; predictive biomarkers; genetic association; genetic polymorphisms; genetic risk; protective variant CD24; meta-analysis; multiple sclerosis; predictive biomarkers; genetic association; genetic polymorphisms; genetic risk; protective variant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Braliou, G.G.; Pantavou, K.G.; Kontou, P.I.; Bagos, P.G. Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis. Int. J. Mol. Sci. 2015, 16, 12368-12381.

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