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Int. J. Mol. Sci. 2015, 16(6), 12185-12198; doi:10.3390/ijms160612185

The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis

Istituto di Bioimmagini e Fisiologia Molecolare (IBFM), National Research Council (CNR), Catanzaro 88100, Italy
Institute of Neurology, University Magna Graecia, Germaneto, Catanzaro 88100, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 31 March 2015 / Revised: 20 May 2015 / Accepted: 26 May 2015 / Published: 28 May 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
View Full-Text   |   Download PDF [647 KB, uploaded 28 May 2015]   |  


In recent years, a high number of studies have demonstrated that neuropsychological functions are altered in multiple sclerosis (MS) patients with cerebellar lesions, mainly including attention, working memory and verbal fluency. Since the present literature is often elusive on this topic, we aim to provide a comprehensive report about the real impact of cerebellar damages (evaluated as volume, lesions or connectivity measures) on cognitive functions. In particular in this review, we report and discuss recent works from 2009 to 2015, which have demonstrated the key role of the cerebellum in cognitive impairment of MS patients. View Full-Text
Keywords: cerebellum; multiple sclerosis (MS); magnetic resonance imaging (MRI); cognitive impairment; executive functions cerebellum; multiple sclerosis (MS); magnetic resonance imaging (MRI); cognitive impairment; executive functions

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sarica, A.; Cerasa, A.; Quattrone, A. The Neurocognitive Profile of the Cerebellum in Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 12185-12198.

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