Special Issue "Pathogenesis of Cardiac Arrhythmias and Heart Failure"
Deadline for manuscript submissions: closed (30 November 2014)
Prof. Yi-Han Chen (Website)
Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Interests: the mechanisms of cardiac arrhythmias and heart failure
Prof. Jianmin Cui (Website)
Department of Biomedical Engineering, Washington University, One Brookings Drive, Saint Louis, MO 63130, USA
Interests: molecular basis of bioelectricity and related diseases in nervous and cardiovascular systems; including ion channel function; modulation; ion channel associated diseases; and discovery of drugs that target ion channels
Cardiac arrhythmias are any of a group of conditions in which the electrical activity of the heart is irregular or is faster or slower than normal. Up to 50% of patients die suddenly at the first manifestation of cardiac diseases; the majority of these patients die of ventricular fibrillation, a lethal cardiac arrhythmia. Heart failure, a syndrome characterized by inadequate systemic perfusion owing to reduced cardiac pumping, is the most common cause of hospitalization of cardiovascular diseases and imposes a great burden on the healthcare system and society.
Cardiac arrhythmias and heart failure are usually interwoven and react with each other; they have been a prevailing public health problem among humans across all ages. Understanding the pathogenesis of cardiac arrhythmias and heart failure is critical to the development of diagnostic, treatment and preventive strategies. The current understanding of electrophysiological mechanisms of cardiac arrhythmias includes automaticity, triggered activity and reentry, and an understanding of pathogenetic mechanisms of heart failure includes a multitude of biomechanical, hemodynamic, hormonal and pathologic stimuli. However, the molecular pathways of cardiac arrhythmias and heart failure are still elusive, and novel molecular defects and pathways remain to be identified for screening, molecular diagnosis, drug-target development, and personalized medicine.
The special issue seeks the original contribution of work which addresses novel mechanisms of cardiac arrhythmias and heart failure. In particular, major interests will be findings in cellular logistics (endocytosis; exocytosis; molecule trafficking; molecular docking machinery, etc.), organelles (mitochondria, sarcoplasmic reticulum, lysosome and endosome, etc.), ion channels, cell electrophysiology, genetic and epigenetic regulations, molecular and cellular biology, physiology, pathophysiology and pharmacology.
Prof. Yi-Han Chen
Prof. Jianmin Cui
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- cardiac arrhythmias
- heart failure
- physiology and pathophysiology
- molecular and cellular biology
- cell and in vivo electrophysiology
- cellular logistics
- ion channels
- genetic and epigenetic regulations