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Int. J. Mol. Sci. 2015, 16(2), 4327-4342; doi:10.3390/ijms16024327

Introducing a Semi-Coated Model to Investigate Antibacterial Effects of Biocompatible Polymers on Titanium Surfaces

1
Clinic for Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
2
Institute for Technical Chemistry, Braunschweig University of Technology, Hans-Sommer-Str. 10, D-38104 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Antonella Piozzi
Received: 18 November 2014 / Accepted: 12 February 2015 / Published: 17 February 2015
(This article belongs to the Special Issue Antimicrobial Polymers)
View Full-Text   |   Download PDF [4735 KB, uploaded 17 February 2015]   |  

Abstract

Peri-implant infections from bacterial biofilms on artificial surfaces are a common threat to all medical implants. They are a handicap for the patient and can lead to implant failure or even life-threatening complications. New implant surfaces have to be developed to reduce biofilm formation and to improve the long-term prognosis of medical implants. The aim of this study was (1) to develop a new method to test the antibacterial efficacy of implant surfaces by direct surface contact and (2) to elucidate whether an innovative antimicrobial copolymer coating of 4-vinyl-N-hexylpyridinium bromide and dimethyl(2-methacryloyloxyethyl) phosphonate (VP:DMMEP 30:70) on titanium is able to reduce the attachment of bacteria prevalent in peri-implant infections. With a new in vitro model with semi-coated titanium discs, we were able to show a dramatic reduction in the adhesion of various pathogenic bacteria (Streptococcus sanguinis, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis), completely independently of effects caused by soluble materials. In contrast, soft tissue cells (human gingival or dermis fibroblasts) were less affected by the same coating, despite a moderate reduction in initial adhesion of gingival fibroblasts. These data confirm the hypothesis that VP:DMMEP 30:70 is a promising antibacterial copolymer that may be of use in several clinical applications. View Full-Text
Keywords: antimicrobial surface; polymer coating; bacteria; biofilm; implants; experiments in vitro antimicrobial surface; polymer coating; bacteria; biofilm; implants; experiments in vitro
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Winkel, A.; Dempwolf, W.; Gellermann, E.; Sluszniak, M.; Grade, S.; Heuer, W.; Eisenburger, M.; Menzel, H.; Stiesch, M. Introducing a Semi-Coated Model to Investigate Antibacterial Effects of Biocompatible Polymers on Titanium Surfaces. Int. J. Mol. Sci. 2015, 16, 4327-4342.

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