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Int. J. Mol. Sci. 2015, 16(2), 3980-3989; doi:10.3390/ijms16023980

Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

1
Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan
2
Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan
3
School of Pharmacy, China Medical University, Taichung 40402, Taiwan
4
Research Center for Chinese Herbal Medicine, China Medical University, Taichung 40402, Taiwan
5
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40402, Taiwan
6
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
7
Center of Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 15 January 2015 / Revised: 2 February 2015 / Accepted: 2 February 2015 / Published: 12 February 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [709 KB, uploaded 12 February 2015]   |  

Abstract

Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl) phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. View Full-Text
Keywords: Cephalantheropsis gracilis; Orchidaceae; quinazoline; tryptanthrin; indolotryptanthrin; dihydrophenanthrene; cytotoxicity Cephalantheropsis gracilis; Orchidaceae; quinazoline; tryptanthrin; indolotryptanthrin; dihydrophenanthrene; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, C.-F.; Hsu, Y.-L.; Lee, C.-Y.; Wu, C.-H.; Wu, Y.-C.; Chuang, T.-H. Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis. Int. J. Mol. Sci. 2015, 16, 3980-3989.

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