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Int. J. Mol. Sci. 2015, 16(2), 3970-3979; doi:10.3390/ijms16023970

Regulation of Translation Factor EEF1D Gene Function by Alternative Splicing

1
Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
2
Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 19 December 2014 / Accepted: 4 February 2015 / Published: 12 February 2015
(This article belongs to the Special Issue Pre-mRNA Splicing)
View Full-Text   |   Download PDF [930 KB, uploaded 12 February 2015]   |  

Abstract

Alternative splicing is an exquisite mechanism that allows one coding gene to have multiple functions. The alternative splicing machinery is necessary for proper development, differentiation and stress responses in a variety of organisms, and disruption of this machinery is often implicated in human diseases. Previously, we discovered a long form of eukaryotic elongation factor 1Bδ (eEF1Bδ; this long-form eEF1Bδ results from alternative splicing of EEF1D transcripts and regulates the cellular stress response by transcriptional activation, not translational enhancement, of heat-shock responsive genes. In this review, we discuss the molecular function of EEF1D alternative splicing products and the estimated implication of human diseases. View Full-Text
Keywords: elongation factor; alternative splicing; heat shock; stress response elongation factor; alternative splicing; heat shock; stress response
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kaitsuka, T.; Matsushita, M. Regulation of Translation Factor EEF1D Gene Function by Alternative Splicing. Int. J. Mol. Sci. 2015, 16, 3970-3979.

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