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Int. J. Mol. Sci. 2015, 16(2), 3237-3250; doi:10.3390/ijms16023237

Infiltrating Mast Cells Correlate with Angiogenesis in Bone Metastases from Gastric Cancer Patients

1
Department of Medical and Surgical Sciences, Clinical Surgery Unit, University "Magna Graecia" Medical School, Viale Europa, Germaneto, Catanzaro 88100, Italy
2
Surgery Unit, National Cancer Research Centre Istituto Tumori "Giovanni Paolo II", viale Orazio Flacco 65, Bari 70124, Italy
3
Diagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, Istituto Tumori "Giovanni Paolo II", viale Orazio Flacco 65, Bari 70124, Italy
4
Chair of Pathology, Veterinary Medical School, University "Aldo Moro" of Bari, Via Casamassima, Bari 70010, Italy
5
Department of Emergency and Organ Transplantation (D.E.T.O.), Veterinary Medical School, Università "Aldo Moro", Via Casamassima, Bari 70010, Italy
6
Pathology Unit, ASL BA, Contrada Capo Scardicchio 92, Bari 70100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 19 November 2014 / Accepted: 26 January 2015 / Published: 2 February 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [845 KB, uploaded 2 February 2015]   |  

Abstract

While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by AJCC for Gastric Cancer Staging 7th Edition) BMGCP from bone biopsies were selected. Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of MCs density positive to tryptase (MCDPT), MCs area positive to tryptase (MCAPT), microvascular density (MVD) and endothelial area (EA). A significant correlation between MCDPT, MCAPT, MVD and EA groups to each other was found by Pearson and t-test analysis (r ranged from 0.68 to 0.82; p-value ranged from 0.00 to 0.02). Our very preliminary data suggest that infiltrating MCs positive for tryptase may play a role in BMGCP angiogenesis, and could be further evaluated as a novel target of anti-angiogenic therapy. View Full-Text
Keywords: gastric cancer; bone metastases; mast cells; tryptase; anti-angiogenetic therapy gastric cancer; bone metastases; mast cells; tryptase; anti-angiogenetic therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ammendola, M.; Marech, I.; Sammarco, G.; Zuccalà, V.; Luposella, M.; Zizzo, N.; Patruno, R.; Crovace, A.; Ruggieri, E.; Zito, A.F.; Gadaleta, C.D.; Sacco, R.; Ranieri, G. Infiltrating Mast Cells Correlate with Angiogenesis in Bone Metastases from Gastric Cancer Patients. Int. J. Mol. Sci. 2015, 16, 3237-3250.

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