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Int. J. Mol. Sci. 2015, 16(2), 3133-3147; doi:10.3390/ijms16023133

Heart Failure and Atrial Fibrillation: From Basic Science to Clinical Practice

Internal Medicine Department, Centro Hospitalar do Porto, Porto 4099-001, Portugal
Department of Physiology and Cardiothoracic Surgery, Cardiovascular Research and Development Unit, Faculty of Medicine, University of Porto, Porto 4200-319, Portugal
Cardiology Department, Centro Hospitalar do Porto, Porto 4099-001, Portugal
Author to whom correspondence should be addressed.
Academic Editor: Yi-Han Chen
Received: 29 November 2014 / Accepted: 27 January 2015 / Published: 30 January 2015
(This article belongs to the Special Issue Pathogenesis of Cardiac Arrhythmias and Heart Failure)
View Full-Text   |   Download PDF [1018 KB, uploaded 30 January 2015]   |  


Heart failure (HF) and atrial fibrillation (AF) are two growing epidemics associated with significant morbidity and mortality. They often coexist due to common risk factors and shared pathophysiological mechanisms. Patients presenting with both HF and AF have a worse prognosis and present a particular therapeutic challenge to clinicians. This review aims to appraise the common pathophysiological background, as well as the prognostic and therapeutic implications of coexistent HF and AF. View Full-Text
Keywords: atrial fibrillation (AF); heart failure (HF); pathophysiology atrial fibrillation (AF); heart failure (HF); pathophysiology

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ferreira, J.P.; Santos, M. Heart Failure and Atrial Fibrillation: From Basic Science to Clinical Practice. Int. J. Mol. Sci. 2015, 16, 3133-3147.

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