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Int. J. Mol. Sci. 2015, 16(2), 2810-2823; doi:10.3390/ijms16022810

Detection of miRNA as Non-Invasive Biomarkers of Colorectal Cancer

1,2
,
1,3
,
1
and
1,*
1
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
2
Weinberg College of Arts and Sciences, Northwestern University, 633 Clark Street, Evanston, IL 60208, USA
3
Division of Colorectal Surgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Camile S. Farah
Received: 3 November 2014 / Accepted: 15 January 2015 / Published: 27 January 2015
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
View Full-Text   |   Download PDF [676 KB, uploaded 27 January 2015]

Abstract

Colorectal Cancer (CRC) is one of the deadliest cancers—ranking as the fourth most common cause of cancer-related deaths in the world. It is such a deadly disease because it is largely asymptomatic until the latter stages—oftentimes when the cancer has metastasized. Thus, a huge emphasis of cancer treatment is placed on early detection. Currently, there is a lack of a noninvasive, reliable, and cost-effective screening method for CRC. In recent years, microRNA (miRNA) diagnostic markers have been suggested as a viable new screening method for CRC. miRNAs play an important role in carcinogenesis, and has been observed to be dysregulated in many cancers including CRC. This review examines the diagnostic potential of circulatory and fecal miRNA markers in relation to CRC, as well as current techniques to detect them. View Full-Text
Keywords: colorectal cancer; miRNA; circulatory; fecal; biomarker; diagnostic colorectal cancer; miRNA; circulatory; fecal; biomarker; diagnostic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ren, A.; Dong, Y.; Tsoi, H.; Yu, J. Detection of miRNA as Non-Invasive Biomarkers of Colorectal Cancer. Int. J. Mol. Sci. 2015, 16, 2810-2823.

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