Next Article in Journal
Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome
Next Article in Special Issue
FBXW7 Acts as an Independent Prognostic Marker and Inhibits Tumor Growth in Human Osteosarcoma
Previous Article in Journal
Lipid Metabolism, Apoptosis and Cancer Therapy
Previous Article in Special Issue
Connexin 43 Suppresses Tumor Angiogenesis by Down-Regulation of Vascular Endothelial Growth Factor via Hypoxic-Induced Factor-1α
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(1), 950-965; doi:10.3390/ijms16010950

Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism

1
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
2
Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 6591, Lubbock, TX 79430-6591, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 15 November 2014 / Accepted: 24 December 2014 / Published: 5 January 2015
(This article belongs to the Special Issue Advances in Molecular Oncology 2014)
View Full-Text   |   Download PDF [717 KB, uploaded 5 January 2015]   |  

Abstract

SIRT1, an NAD+-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in response to diverse physiological stress. Interestingly, many of the metabolic pathways that are influenced by SIRT1 are also altered in tumor development. Not only does SIRT1 have the potential to regulate oncogenic factors, it also orchestrates many aspects of metabolism and lipid regulation and recent reports are beginning to connect these areas. SIRT1 influences pathways that provide an alternative means of deriving energy (such as fatty acid oxidation and gluconeogenesis) when a cell encounters nutritive stress, and can therefore lead to altered lipid metabolism in various pathophysiological contexts. This review helps to show the various connections between SIRT1 and major pathways in cellular metabolism and the consequence of SIRT1 deregulation on carcinogenesis and lipid metabolism. View Full-Text
Keywords: sirtuin; SIRT1; metabolism; cancer; lipolysis; lipids; steatosis; fatty acid; sterol regulatory element-binding protein (SREBP) sirtuin; SIRT1; metabolism; cancer; lipolysis; lipids; steatosis; fatty acid; sterol regulatory element-binding protein (SREBP)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Simmons, G.E., Jr.; Pruitt, W.M.; Pruitt, K. Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism. Int. J. Mol. Sci. 2015, 16, 950-965.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top