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Int. J. Mol. Sci. 2015, 16(1), 966-989; doi:10.3390/ijms16010966

Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome

1
Greehey Children's Cancer Research Center, University of Texas Health Science Center San Antonio (UTHSCSA), 8403 Floyd Curl Drive, San Antonio, TX 78229, USA
2
Department of Cellular and Structural Biology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
3
Department of Hematology, Northern Jiangsu People's Hospital, Yangzhou 225001, China
4
The Cancer Therapy Research Center, UTHSCSA, 7979 Wurzbach Road, San Antonio, TX 78229, USA
5
Barshop Institute for Longevity and Aging Studies, UTHSCSA, Texas Research Park Campus, 15355 Lambda Drive, San Antonio, TX 78245, USA
6
The University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Street, Woolloongabba, QLD 4102, Australia
7
Department of Molecular Medicine, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Guillermo T. Sáez
Received: 5 November 2014 / Accepted: 22 December 2014 / Published: 5 January 2015
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases 2014)
View Full-Text   |   Download PDF [1177 KB, uploaded 5 January 2015]   |  

Abstract

Hematopoietic stem cells (HSCs) are responsible for the continuous regeneration of all types of blood cells, including themselves. To ensure the functional and genomic integrity of blood tissue, a network of regulatory pathways tightly controls the proliferative status of HSCs. Nevertheless, normal HSC aging is associated with a noticeable decline in regenerative potential and possible changes in other functions. Myelodysplastic syndrome (MDS) is an age-associated hematopoietic malignancy, characterized by abnormal blood cell maturation and a high propensity for leukemic transformation. It is furthermore thought to originate in a HSC and to be associated with the accrual of multiple genetic and epigenetic aberrations. This raises the question whether MDS is, in part, related to an inability to adequately cope with DNA damage. Here we discuss the various components of the cellular response to DNA damage. For each component, we evaluate related studies that may shed light on a potential relationship between MDS development and aberrant DNA damage response/repair. View Full-Text
Keywords: myelodysplastic syndrome; hematopoietic stem cells; DNA damage response/repair; aging myelodysplastic syndrome; hematopoietic stem cells; DNA damage response/repair; aging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhou, T.; Chen, P.; Gu, J.; Bishop, A.J.R.; Scott, L.M.; Hasty, P.; Rebel, V.I. Potential Relationship between Inadequate Response to DNA Damage and Development of Myelodysplastic Syndrome. Int. J. Mol. Sci. 2015, 16, 966-989.

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