Next Article in Journal
Effects of Different Sera Conditions on Olfactory Ensheathing Cells in Vitro
Next Article in Special Issue
Chlamydia pneumoniae and Oxidative Stress in Cardiovascular Disease: State of the Art and Prevention Strategies
Previous Article in Journal
Oxidative Stress in Obesity: A Critical Component in Human Diseases
Previous Article in Special Issue
The Role of Reactive Oxygen Species in Microvascular Remodeling
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(1), 401-419; doi:10.3390/ijms16010401

Lipoprotein-Associated Oxidative Stress: A New Twist to the Postprandial Hypothesis

Fellow, American Heart Association, Laboratory Director, Biomarker Core Laboratory, Atlanta Research and Education Foundation, Atlanta VA Medical Center, Decatur, GA 30033, USA
Academic Editor: Francis Miller
Received: 18 November 2014 / Accepted: 16 December 2014 / Published: 26 December 2014
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
View Full-Text   |   Download PDF [922 KB, uploaded 26 December 2014]   |  

Abstract

Oxidative stress is recognized as one of the primary processes underlying the initiation and progression of atherosclerotic vascular disease. Under physiological conditions, the balance between reactive oxygen species (ROS) generation and ROS scavenging is tightly controlled. As part of normal cellular metabolism, regulated oxidative stress is responsible for a variety of cellular responses. Excess generation of ROS that could not be compensated by antioxidant system has been suggested to be responsible for a number of pathological conditions. Due to their short biological half-lives, direct measurement of ROS is not available and surrogate measures are commonly used. Plasma lipoproteins, by virtue of their close interactions with endothelial cells in the vasculature and the susceptibility of their surface lipids to oxidative modification, are perfect biological sensors of oxidative stress in the arterial wall. In particular, with each consumed meal, triglyceride-rich lipoproteins, secreted by the intestine into the circulation, are responsible for the delivery of 20–40 grams of fat to the peripheral tissues. This flux of dietary lipids is accompanied by concomitant increases in glucose, insulin and other meal-associated metabolites. The contribution of postprandial lipemia to the pathogenesis of atherosclerosis has been previously suggested by several lines of investigation. We have extended this hypothesis by demonstrating the acute generation of oxidative epitopes on plasma lipoproteins as well as transient changes in the oxidative susceptibility of plasma lipoproteins. View Full-Text
Keywords: oxidative stress; reactive oxygen species; lipoproteins; postprandial lipemia oxidative stress; reactive oxygen species; lipoproteins; postprandial lipemia
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Le, N.-A. Lipoprotein-Associated Oxidative Stress: A New Twist to the Postprandial Hypothesis. Int. J. Mol. Sci. 2015, 16, 401-419.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top