Next Article in Journal
Rise-Time of FRET-Acceptor Fluorescence Tracks Protein Folding
Next Article in Special Issue
Lipoprotein-Associated Oxidative Stress: A New Twist to the Postprandial Hypothesis
Previous Article in Journal
When Isolated at Full Receptivity, in Vitro Fertilized Wheat (Triticum aestivum, L.) Egg Cells Reveal [Ca2+]cyt Oscillation of Intracellular Origin
Previous Article in Special Issue
l-Cystathionine Inhibits the Mitochondria-Mediated Macrophage Apoptosis Induced by Oxidized Low Density Lipoprotein
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(12), 23792-23835; doi:10.3390/ijms151223792

The Role of Reactive Oxygen Species in Microvascular Remodeling

Dalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
*
Author to whom correspondence should be addressed.
Received: 30 October 2014 / Revised: 5 December 2014 / Accepted: 10 December 2014 / Published: 19 December 2014
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
View Full-Text   |   Download PDF [1139 KB, uploaded 19 December 2014]   |  

Abstract

The microcirculation is a portion of the vascular circulatory system that consists of resistance arteries, arterioles, capillaries and venules. It is the place where gases and nutrients are exchanged between blood and tissues. In addition the microcirculation is the major contributor to blood flow resistance and consequently to regulation of blood pressure. Therefore, structural remodeling of this section of the vascular tree has profound implications on cardiovascular pathophysiology. This review is focused on the role that reactive oxygen species (ROS) play on changing the structural characteristics of vessels within the microcirculation. Particular attention is given to the resistance arteries and the functional pathways that are affected by ROS in these vessels and subsequently induce vascular remodeling. The primary sources of ROS in the microcirculation are identified and the effects of ROS on other microcirculatory remodeling phenomena such as rarefaction and collateralization are briefly reviewed. View Full-Text
Keywords: resistance arteries; microcirculation; inward remodeling; NADPH oxidase; Nox; xanthine oxidase; mitochondria; superoxide; hypertension resistance arteries; microcirculation; inward remodeling; NADPH oxidase; Nox; xanthine oxidase; mitochondria; superoxide; hypertension
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Staiculescu, M.C.; Foote, C.; Meininger, G.A.; Martinez-Lemus, L.A. The Role of Reactive Oxygen Species in Microvascular Remodeling. Int. J. Mol. Sci. 2014, 15, 23792-23835.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top