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Int. J. Mol. Sci. 2015, 16(1), 230-255; doi:10.3390/ijms16010230

The Potential of Liposomes with Carbonic Anhydrase IX to Deliver Anticancer Ingredients to Cancer Cells in Vivo

1
,
1,2,†
,
3,†
,
4,†
and
1,2,*
1
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong 999077, China
2
Changshu Research Institute, Hong Kong Baptist University, Changshu Economic and Technological Development (CETD) Zone, Changshu 215500, China
3
School of Biomedical Sciences, Chinese University of Hong Kong, Area 39, CUHK, Shatin, NT, Hong Kong 999077, China
4
Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong 999077, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Bing Yan
Received: 4 November 2014 / Accepted: 16 December 2014 / Published: 24 December 2014
(This article belongs to the Special Issue Bioactive Nanoparticles 2014)
View Full-Text   |   Download PDF [1060 KB, uploaded 24 December 2014]   |  

Abstract

Drug delivery nanocarriers, especially targeted drug delivery by liposomes are emerging as a class of therapeutics for cancer. Early research results suggest that liposomal therapeutics enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumors and active cellular uptake. Here, we highlight the features of immunoliposomes that distinguish them from previous anticancer therapies, and describe how these features provide the potential for therapeutic effects that are not achievable with other modalities. While a large number of studies has been published, the emphasis here is placed on the carbonic anhydrase IX (CA-IX) and the conjugated liposomes that are likely to open a new chapter on drug delivery system by using immunoliposomes to deliver anticancer ingredients to cancer cells in vivo. View Full-Text
Keywords: immunoliposomes; anticancer ingredients; in vivo delivery; carbonic anhydronase IX (CA-IX); cancer cell penetrating peptides immunoliposomes; anticancer ingredients; in vivo delivery; carbonic anhydronase IX (CA-IX); cancer cell penetrating peptides
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Ng, H.L.H.; Lu, A.; Lin, G.; Qin, L.; Yang, Z. The Potential of Liposomes with Carbonic Anhydrase IX to Deliver Anticancer Ingredients to Cancer Cells in Vivo. Int. J. Mol. Sci. 2015, 16, 230-255.

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