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Int. J. Mol. Sci. 2015, 16(1), 2145-2161; doi:10.3390/ijms16012145

Unravelling Genes and Pathways Implicated in Working Memory of Schizophrenia in Han Chinese

1
Mental Health Center, West China Hospital, Sichuan University, 28 Dian Xin Nan Road, Chengdu 610041, China
2
State Key Laboratory of Biotherapy, Psychiatric Laboratory, West China Hospital, Sichuan University, 1 Ke Yuan 4 Road, Hi-Tech Developmental Zone, Chengdu 610041, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 13 October 2014 / Revised: 5 November 2014 / Accepted: 12 January 2015 / Published: 20 January 2015
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1518 KB, uploaded 20 January 2015]   |  

Abstract

Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify the factors underlying working memory deficit in schizophrenia patients and to explore the implication of possible genes in the working memory using genome-wide association study (GWAS) of schizophrenia, computerized delay-matching-to-sample (DMS) and whole genome genotyping data were obtained from 100 first-episode, treatment-naïve patients with schizophrenia and 140 healthy controls from the Mental Health Centre of the West China Hospital, Sichuan University. A composite score, delay-matching-to-sample total correct numbers (DMS-TC), was found to be significantly different between the patients and control. On associating quantitative DMS-TC with interactive variables of groups × genotype, one SNP (rs1411832), located downstream of YWHAZP5 in chromosome 10, was found to be associated with the working memory deficit in schizophrenia patients with lowest p-value (p = 2.02 × 10−7). ConsensusPathDB identified that genes with SNPs for which p values below the threshold of 5 × 10−5 were significantly enriched in GO:0007155 (cell adhesion, p < 0.001). This study indicates that working memory, as an endophenotype of schizophrenia, could improve the efficacy of GWAS in schizophrenia. However, further study is required to replicate the results from our study. View Full-Text
Keywords: working memory; delayed-matching-to-sample test; schizophrenia; genome-wide association study; pathway working memory; delayed-matching-to-sample test; schizophrenia; genome-wide association study; pathway
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ren, H.; Zhang, C.; Huang, C.; Li, N.; Li, M.; Li, Y.; Deng, W.; Ma, X.; Xiang, B.; Wang, Q.; Li, T. Unravelling Genes and Pathways Implicated in Working Memory of Schizophrenia in Han Chinese. Int. J. Mol. Sci. 2015, 16, 2145-2161.

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