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Int. J. Mol. Sci. 2015, 16(1), 2117-2129; doi:10.3390/ijms16012117

Prevention of Osteoporosis by Oral Administration of Phytate-Removed and Deamidated Soybean β-Conglycinin

1
Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan
2
Department of Food Business, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan
3
Department of Food Science and Nutrition, Kyoritsu Women's University, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo 101-8437, Japan
*
Author to whom correspondence should be addressed.
Received: 16 November 2014 / Accepted: 13 January 2015 / Published: 19 January 2015
(This article belongs to the Special Issue Bioactive Proteins and Peptides Derived from Food)
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Abstract

Phytate-removed and deamidated soybean β-conglycinin (PrDS) prepared by ion-exchange resins was supplemented to be 4% in the diet administered to ovariectomized rats to investigate its preventive effect on osteoporosis. The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein. On the other hand, administration of PrDS restored the calcium absorption rate to the same level as the sham group. Markers of bone resorption, such as serum parathyroid hormone (PTH) and urinary deoxypyridinoline (DPD), increased, and the bone mineral density and breaking stress decreased following ovariectomy. However, PrDS supplementation suppressed the changes caused by the decrease in calcium absorption from the small intestine. Therefore, PrDS supplementation shows promise for the prevention of postmenopausal osteoporosis. View Full-Text
Keywords: phytate removal; deamidation; soybean β-conglycinin; ovariectomy; postmenopausal osteoporosis phytate removal; deamidation; soybean β-conglycinin; ovariectomy; postmenopausal osteoporosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Akao, M.; Abe, R.; Sato, N.; Hasegawa-Tanigome, A.; Kumagai, H.; Kumagai, H. Prevention of Osteoporosis by Oral Administration of Phytate-Removed and Deamidated Soybean β-Conglycinin. Int. J. Mol. Sci. 2015, 16, 2117-2129.

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