Next Article in Journal
Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways
Next Article in Special Issue
Cartilage Oligomeric Matrix Protein Gene Multilayers Inhibit Osteogenic Differentiation and Promote Chondrogenic Differentiation of Mesenchymal Stem Cells
Previous Article in Journal
Brain Metastases in Gastrointestinal Cancers: Is there a Role for Surgery?
Previous Article in Special Issue
Epitaxial Relationships between Calcium Carbonate and Inorganic Substrates
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(9), 16831-16847; doi:10.3390/ijms150916831

Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems

1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
2
Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
3
Institute for Engineering of Polymer Materials and Dies, ul. Marii Skłodowskiej-Curie 55, 87-100 Toruń, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 June 2014 / Revised: 5 August 2014 / Accepted: 12 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Biomimetic and Functional Materials)
View Full-Text   |   Download PDF [13277 KB, uploaded 22 September 2014]   |  

Abstract

In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems. View Full-Text
Keywords: polymeric biomaterials; bisphosphonates; polyurethanes; hydroxyapatite; drug delivery systems; clodronate polymeric biomaterials; bisphosphonates; polyurethanes; hydroxyapatite; drug delivery systems; clodronate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kolmas, J.; Sobczak, M.; Olędzka, E.; Nałęcz-Jawecki, G.; Dębek, C. Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems. Int. J. Mol. Sci. 2014, 15, 16831-16847.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top