Int. J. Mol. Sci. 2014, 15(9), 16831-16847; doi:10.3390/ijms150916831
Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems
1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
2
Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland
3
Institute for Engineering of Polymer Materials and Dies, ul. Marii Skłodowskiej-Curie 55, 87-100 Toruń, Poland
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 June 2014 / Revised: 5 August 2014 / Accepted: 12 September 2014 / Published: 22 September 2014
(This article belongs to the Special Issue Biomimetic and Functional Materials)
Abstract
In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems. View Full-TextKeywords:
polymeric biomaterials; bisphosphonates; polyurethanes; hydroxyapatite; drug delivery systems; clodronate
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Kolmas, J.; Sobczak, M.; Olędzka, E.; Nałęcz-Jawecki, G.; Dębek, C. Synthesis, Characterization and in Vitro Evaluation of New Composite Bisphosphonate Delivery Systems. Int. J. Mol. Sci. 2014, 15, 16831-16847.
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