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Int. J. Mol. Sci. 2014, 15(9), 15689-15699; doi:10.3390/ijms150915689

EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation

1
Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang 110016, China
2
Institute of Neuroscience, Fourth Military Medical University, Xi'an 710032, China
*
Author to whom correspondence should be addressed.
Received: 7 May 2014 / Revised: 27 June 2014 / Accepted: 28 August 2014 / Published: 4 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics. View Full-Text
Keywords: factor binding IST-1; specificity protein-1; endothelial pas domain protein-1; transcription factor; tumorigenesis factor binding IST-1; specificity protein-1; endothelial pas domain protein-1; transcription factor; tumorigenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, X.; Cao, P.; Li, Z.; Wu, D.; Wang, X.; Liang, G. EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation. Int. J. Mol. Sci. 2014, 15, 15689-15699.

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