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Int. J. Mol. Sci. 2014, 15(9), 15679-15688; doi:10.3390/ijms150915679

Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella antipathies

1
Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
2
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
3
Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
5
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
6
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
7
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
8
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Graduate Institute of Marine Biology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
11
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 3 July 2014 / Revised: 21 August 2014 / Accepted: 26 August 2014 / Published: 4 September 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [771 KB, uploaded 4 September 2014]   |  

Abstract

Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils. View Full-Text
Keywords: Rumphella antipathies; sesquiterpene; caryophyllene; rumphellol; superoxide anion; elastase Rumphella antipathies; sesquiterpene; caryophyllene; rumphellol; superoxide anion; elastase
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MDPI and ACS Style

Chung, H.-M.; Wang, W.-H.; Hwang, T.-L.; Chen, J.-J.; Fang, L.-S.; Wen, Z.-H.; Wang, Y.-B.; Wu, Y.-C.; Sung, P.-J. Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella antipathies. Int. J. Mol. Sci. 2014, 15, 15679-15688.

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