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Int. J. Mol. Sci. 2014, 15(8), 14456-14474; doi:10.3390/ijms150814456

Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa

Department of Ophthalmology, Second Hospital, Jilin University, Ziqiang Street No. 218, Changchun 130041, Jilin, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 24 April 2014 / Revised: 24 July 2014 / Accepted: 11 August 2014 / Published: 20 August 2014
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Abstract

Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment. View Full-Text
Keywords: retinitis pigmentosa; bone marrow-derived mesenchymal stem cells; stem cell transplantation retinitis pigmentosa; bone marrow-derived mesenchymal stem cells; stem cell transplantation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

He, Y.; Zhang, Y.; Liu, X.; Ghazaryan, E.; Li, Y.; Xie, J.; Su, G. Recent Advances of Stem Cell Therapy for Retinitis Pigmentosa. Int. J. Mol. Sci. 2014, 15, 14456-14474.

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