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Int. J. Mol. Sci. 2014, 15(8), 14014-14025; doi:10.3390/ijms150814014

Silver Nanoparticles/Ibuprofen-Loaded Poly(l-lactide) Fibrous Membrane: Anti-Infection and Anti-Adhesion Effects

4,* and 1,*
Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China
Department of Orthopaedic, Yuhuangding Hospital of Yantai, 20 Yuhuangding East Road, Yantai 264000, China
Department of Orthopaedics and Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China
Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou 215006, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 10 June 2014 / Revised: 14 July 2014 / Accepted: 24 July 2014 / Published: 12 August 2014
(This article belongs to the Special Issue Antimicrobial Polymers)
View Full-Text   |   Download PDF [3606 KB, uploaded 12 August 2014]   |  


Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(l-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane. Inferior adherence and proliferation of fibroblasts were found on the Ag4%–IBU4%-loaded PLLA electrospun fibrous membranes in comparison with pure PLLA and 4% Ag-loaded PLLA membranes. In the antibacterial test, all Ag-loaded PLLA electrospun fibrous membranes prevented the adhesion of Staphylococcus aureus and Staphylococcus epidermidis. Taken together, these results demonstrate that Ibuprofen is effective in enhancing the anti-adhesion and anti-proliferation effects of 4% Ag-loaded PLLA fibrous membrane. The medical potential of infection reduction and adhesion prevention of Ag4%–IBU4%-loaded PLLA electrospun fibrous membrane deserves to be further studied. View Full-Text
Keywords: peritendinous adhesions; antimicrobial polymers; electrospun membrane; silver nanoparticle; ibuprofen peritendinous adhesions; antimicrobial polymers; electrospun membrane; silver nanoparticle; ibuprofen

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Chen, S.; Wang, G.; Wu, T.; Zhao, X.; Liu, S.; Li, G.; Cui, W.; Fan, C. Silver Nanoparticles/Ibuprofen-Loaded Poly(l-lactide) Fibrous Membrane: Anti-Infection and Anti-Adhesion Effects. Int. J. Mol. Sci. 2014, 15, 14014-14025.

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