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Int. J. Mol. Sci. 2014, 15(8), 14014-14025; doi:10.3390/ijms150814014

Silver Nanoparticles/Ibuprofen-Loaded Poly(l-lactide) Fibrous Membrane: Anti-Infection and Anti-Adhesion Effects

1,†
,
2,†
,
3,†
,
4
,
1,†
,
3
,
4,* and 1,*
1
Department of Orthopaedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China
2
Department of Orthopaedic, Yuhuangding Hospital of Yantai, 20 Yuhuangding East Road, Yantai 264000, China
3
Department of Orthopaedics and Traumatology, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China
4
Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou 215006, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 10 June 2014 / Revised: 14 July 2014 / Accepted: 24 July 2014 / Published: 12 August 2014
(This article belongs to the Special Issue Antimicrobial Polymers)
View Full-Text   |   Download PDF [3606 KB, uploaded 12 August 2014]   |  

Abstract

Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(l-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane. Inferior adherence and proliferation of fibroblasts were found on the Ag4%–IBU4%-loaded PLLA electrospun fibrous membranes in comparison with pure PLLA and 4% Ag-loaded PLLA membranes. In the antibacterial test, all Ag-loaded PLLA electrospun fibrous membranes prevented the adhesion of Staphylococcus aureus and Staphylococcus epidermidis. Taken together, these results demonstrate that Ibuprofen is effective in enhancing the anti-adhesion and anti-proliferation effects of 4% Ag-loaded PLLA fibrous membrane. The medical potential of infection reduction and adhesion prevention of Ag4%–IBU4%-loaded PLLA electrospun fibrous membrane deserves to be further studied. View Full-Text
Keywords: peritendinous adhesions; antimicrobial polymers; electrospun membrane; silver nanoparticle; ibuprofen peritendinous adhesions; antimicrobial polymers; electrospun membrane; silver nanoparticle; ibuprofen
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, S.; Wang, G.; Wu, T.; Zhao, X.; Liu, S.; Li, G.; Cui, W.; Fan, C. Silver Nanoparticles/Ibuprofen-Loaded Poly(l-lactide) Fibrous Membrane: Anti-Infection and Anti-Adhesion Effects. Int. J. Mol. Sci. 2014, 15, 14014-14025.

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